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Studies on Urinary Tract Infections (Recurrent)

The Vaginal Microbiota and Urinary Tract Infection

Ann E Stapleton(2016)

This review describes the relationship between the vaginal microbiome and urinary tract infection. Disruptions in the vaginal microbiome–especially loss of the protective lactobacilli –are associated with increased risk of UTI. Therapies that restore a healthy vaginal microbiome may reduce risk of UTI.

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D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial.

Bojana Kranjčec, Dino Papeš, Silvio Altarac(2014)

This randomized controlled trial of over 300 women showed that drinking 2g of D-mannose daily reduced risk of developing a UTI at about the same level as prophylactic nitrofurantoin. D-mannose had a lower rate of side effects than nitrofurantoin. This study supports the safety and efficacy of D-mannose for UTI prevention.

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Role of D-Mannose in the Prevention of Recurrent Urinary Tract Infections: Evidence from a Systematic Review of the Literature.

Rena Kyriakides, Patrick Jones, Bhaskar K Somani (2020)

This systematic review of the literature examined eight studies, six of which were clinical studies including 695 participants. Overall, studies showed that D-mannose reduced frequency of UTIs in both catheterized and non-catheterized participants. It significantly improved quality of life in those taking the supplement. D-mannose may be a supplementary or alternative treatment for preventing recurrence of UTI.

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Ability of cranberry proanthocyanidins in combination with a probiotic formulation to inhibit in vitro invasion of gut epithelial cells by extra-intestinal pathogenic E. coli.

M.A.Polewski, C.G. Krueger, J.D. Reed, G. Leyer (2016)

This cell culture study showed that combining cranberry-derived proanthocyanidins (PACs) with probiotics reduces the ability of pathogenic E. coli cells to adhere to the gut lining. The gut is a potential source of pathogenic bacteria responsible for UTIs. Therefore, this study shows two different mechanisms by which UTIs may be prevented, and suggests that combining them may yield better results than either one on its own.

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